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Things That Happen in the Brain and Body on Opioids
January 10, 2019
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Why is this medication prescribed?

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Buy acetaminophen online uk

Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers).

It works by changing the way the body senses pain and by cooling the body.

Codeine belongs to a class of medications called opiate (narcotic) analgesics and to a class of medications called antitussives.

When codeine is used to treat pain, it works by changing the way the brain and nervous system respond to pain.

When codeine is used to reduce coughing, it works by decreasing the activity in the part of the brain that causes coughing.

 

How should this medicine be used?

The combination of acetaminophen and codeine comes as a tablet, capsule, and liquid to take by mouth.

It usually is taken every 4 hours as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take acetaminophen and codeine exactly as directed.

If you have taken acetaminophen and codeine for several weeks or longer, do not stop taking the medication without talking to your doctor.

Your doctor may decrease your dose gradually. If you suddenly stop taking acetaminophen and codeine,

you may experience withdrawal symptoms such as restlessness, widened pupils (black circles in the center of the eyes),

teary eyes, irritability, anxiety, runny nose, difficulty falling asleep or staying asleep, yawning, sweating, fast breathing,

fast heartbeat, chills, nausea, loss of appetite, vomiting, diarrhea, stomach cramps, or muscle aches.

 

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

 

What special precautions should I follow?

Before taking acetaminophen and codeine,

-tell your doctor and pharmacist if you are allergic to acetaminophen, codeine, sulfite, any other medications,

or any of the ingredients in acetaminophen and codeine products. Ask your doctor or pharmacist for a list of the ingredients.

-tell your doctor or pharmacist if you are taking or receiving the following monoamine oxidase (MAO) inhibitors or

if you have stopped taking them within the past two weeks: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue,

phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor will

probably tell you not to take acetaminophen and codeine if you are taking one or more of these medications, or have taken them within the past two weeks.
-tell your doctor and pharmacist what other prescription and nonprescription medications,

vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention if you are taking

any of the following: amiodarone (Nexterone, Pacerone); antihistamines (found in cold and allergy medications);

buprenorphine (Belbuca, Butrans, Probuphine); bupropion (Aplenzin, Wellbutrin, Zyban); butorphanol; diuretics (‘water pills’);

medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge),

rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron);

nalbuphine; pentazocine (Talwin); selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro),

fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft);

serotonin and norepinephrine reuptake inhibitors such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq),

milnacipran (Savella), and venlafaxine (Effexor); tramadol (Conzip), trazodone (Oleptro); or tricyclic antidepressants (‘mood elevators’) such as amitriptyline,

clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor),

protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with acetaminophen and

codeine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
-tell your doctor if you have any of the conditions mentioned in the IMPORTANT WARNING section,

a blockage or narrowing of your stomach or intestines, or paralytic ileus (condition in which digested food does not move through the intestines).

Your doctor may tell you not to take acetaminophen and codeine if you have any of these conditions.
-tell your doctor if you have or have ever had seizures, difficulty urinating, or pancreas, gallbladder, or kidney disease.
you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking acetaminophen and codeine.
-tell your doctor if you are breastfeeding. You should not breastfeed while taking acetaminophen and codeine.

Codeine can cause shallow breathing, difficulty or noisy breathing, confusion, more than usual sleepiness, trouble breastfeeding,

or limpness in breastfed infants in breastfed infants.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking acetaminophen and codeine.
-you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
-you should know that acetaminophen and codeine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position.

To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

What should I do if I forget a dose?

This medication usually is taken as needed.
If your doctor has told you to take acetaminophen and codeine regularly,
take the missed dose as soon as you remember it. However,
if it is almost time for the next dose, skip the missed dose and continue your
regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Acetaminophen and codeine may cause side effects.
Tell your doctor if any of these symptoms are severe or do not go away:
constipation
difficulty urinating

What other information should I know?

Keep all appointments with your doctor. Your doctor may order certain
lab tests to check your body’s response to acetaminophen and codeine.

Before having any laboratory test (especially those that involve methylene blue),
tell your doctor and the laboratory personnel that you are taking acetaminophen and codeine.

Do not let anyone else take your medication. Acetaminophen and codeine is a controlled substance.
Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and
nonprescription (over-the-counter) medicines you are taking, as well as any products
such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
It is also important information to carry with you in case of emergencies.

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